A research group led by Project Researcher Junbing He, Professor Yoshiyuki Hirano, and Professor Eiji Shimizu of the Chiba University Research Center for Child Mental Development conducted the world's first study to investigate the relationship between resting-state functional MRI (fMRI) and cognitive function in patients with social anxiety disorder (SAD). The results revealed reduced brain activity in the brain areas responsible for processing bodily sensations in patients with social anxiety disorder, and that brain activity at specific low frequencies (frequency-dependent brain activity) is associated with cognitive functions such as spatial awareness and memory.
This study is expected to deepen our understanding of the neural basis of cognitive dysfunction in SAD and contribute to the establishment of new neural markers using frequency-dependent brain activity indices.
【Information on the outcome】
https://www.chiba-u.ac.jp/news/research-collab/post_606.html (千葉大学)
https://www.amed.go.jp/news/seika/2025_seika_index.html (AMED)
Exploring the correlation between frequency-dependent brain activity and cognitive function in social anxiety disorder
DOI: 10.1016/j.brainresbull.2025.111603
<Authors>
Junbing He, Nadire Aximu, Tokiko Yoshida, Yuko Isobe, Yusuke Sudo, Koji Matsumoto, Eiji Shimizu, Yoshiyuki Hirano
<Journal>
Brain Research Bulletin , November