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Using Brain Structural Neuroimaging Measures to Predict Psychosis Onset for Individuals at Clinical High-Risk


 The onset of psychosis can be predicted before it occurs, using a machine-learning tool which can classify MRI brain scans into those who are healthy and those at risk of a psychotic episode. An international consortium including Shinsuke Koike, Kiyoto Kasai and the other researchers from the University of Tokyo, used the classifier to compare scans from over 2,000 people from 21 global locations.
 About half of the participants had been identified as being clinically at high risk of developing psychosis. Using training data, the classifier was 85% accurate at differentiating between people who were not at risk and those who later experienced overt psychotic symptoms. Using new data, it was 73% accurate.
 This tool could be helpful in future clinical settings, as while most people who experience psychosis make a full recovery, earlier intervention typically leads to better outcomes with less negative impact on people’s lives.

【Information on the outcome】
https://www.u-tokyo.ac.jp/focus/en/press/z0508_00332.html   (The University of Tokyo
https://www.amed.go.jp/news/seika/2024_seika_index.html  (AMED)



Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk
DOI: 10.1038/s41380-024-02426-7

Yinghan Zhu, Norihide Maikusa, Joaquim Radua, Philipp G. Sämann, Paolo Fusar-Poli, Ingrid Agartz, Ole A. Andreassen, Peter Bachman, Inmaculada Baeza, Xiaogang Chen, Sunah Choi, Cheryl M. Corcoran, Bjørn H. Ebdrup, Adriana Fortea, Ranjini RG. Garani, Birte Yding Glenthøj, Louise Birkedal Glenthøj, Shalaila S. Haas, Holly K. Hamilton, Rebecca A. Hayes, Ying He, Karsten Heekeren, Kiyoto Kasai, Naoyuki Katagiri, Minah Kim, Tina D. Kristensen, Jun Soo Kwon, Stephen M. Lawrie, Irina Lebedeva, Jimmy Lee, Rachel L. Loewy, Daniel H. Mathalon, Philip McGuire, Romina Mizrahi, Masafumi Mizuno, Paul Møller, Takahiro Nemoto, Dorte Nordholm, Maria A. Omelchenko, Jayachandra M. Raghava, Jan I. Røssberg, Wulf Rössler, Dean F. Salisbury, Daiki Sasabayashi, Lukasz Smigielski, Gisela Sugranyes, Tsutomu Takahashi, Christian K. Tamnes, Jinsong Tang, Anastasia Theodoridou, Alexander S. Tomyshev, Peter J. Uhlhaas, Tor G. Værnes, Therese A. M. J. van Amelsvoort, James A. Waltz, Lars T. Westlye, Juan H. Zhou, Paul M. Thompson, Dennis Hernaus, Maria Jalbrzikowski, Shinsuke Koike & the ENIGMA Clinical High Risk for Psychosis Working Group

Molecular Psychiatry  2024 February 09