A research group led by Associate Professor Shinsuke Koike, Professor Kiyoto Kasai, and Professor Osamu Abe of the University of Tokyo, Assistant Professor Takuya Ishida of Wakayama Medical University, Professor Yasumasa Okamoto of Hiroshima University, Professor Toshiya Murai of Kyoto University, and Director Mitsuo Kawato of ATR has elucidated dynamic aspects of the aberrancy of the causal connections among the large-scale networks of the multiple psychiatric disorders (Schizophrenia, Major Deppressive Disorder, Bipolar Disorder) using functional brain images obtained from resting-state functional magnetic resonance imaging (rsfMRI). In this study, dynamic causal modeling (DCM) was applied to the large-sample multi-site dataset, and it revealed that limbic network (LIN) was the core abnormal network common to psychiatric disorders. Furthermore, DCM showed disorder-specific abnormal patterns of causal connections across the 7 networks.
These findings suggested that aberrant dynamics among the large-scale networks could be a key biomarker for these transdiagnostic psychiatric disorders.
【Information on the outcome】
Aberrant Large-Scale Network Interactions Across Psychiatric Disorders Revealed by Large-Sample Multi-Site Resting-State Functional Magnetic Resonance Imaging Datasets
DOI : 10.1093/schbul/sbad022
Takuya Ishida, Yuko Nakamura, Saori C Tanaka, Yuki Mitsuyama, Satoshi Yokoyama, Hotaka Shinzato, Eri Itai, Go Okada, Yuko Kobayashi, Takahiko Kawashima, Jun Miyata, Yujiro Yoshihara, Hidehiko Takahashi, Susumu Morita, Shintaro Kawakami, Osamu Abe, Naohiro Okada, Akira Kunimatsu, Ayumu Yamashita, Okito Yamashita, Hiroshi Imamizu, Jun Morimoto, Yasumasa Okamoto, Toshiya Murai, Kiyoto Kasai, Mitsuo Kawato, Shinsuke Koike