Abnormal phase–amplitude coupling characterizes the interictal state in epilepsy

Summary

A research group led by Professor Haruhiko Kishima, Specially Appointed Researcher Yuya Fujita and Professor Takufumi Yanagisawa from Osaka University has elucidated that the phase-amplitude coupling (PAC) of the magnetoencephalogram (MEG) is useful for the diagnosis of epilepsy patients.

In this study, the research group obtained the resting-state MEG and magnetic resonance imaging (MRI) of epileptic patients and healthy participants. Then, they tested whether PAC improves discrimination accuracy for the two groups. The degree of synchronisation between phase and amplitude differed between epileptic patients and healthy subjects, and the discrimination accuracy was the highest, at 90%, using the combination of PAC and deep learning. The results of this research are expected to be useful for the practical application of automated diagnosis of epilepsy.

【Information on the outcome】

https://www.amed.go.jp/news/seika/kenkyu/20220607-01.html (AMED)

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