Elucidation of the mechanism of failure of phase separation control in neurodegenerative diseases
Summary
A joint research team led by Dr. Mori (Nara Medical Univ.), Prof. Sugie (Nara Medical Univ.), Dr. Yoshizawa (Ritsumeikan Univ.), Prof. Saio (Univ. of Tokushima), and Dr. Aiba (Nagoya Univ.) has revealed the molecular mechanism by which toxic peptides are produced in Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD). The results of this study are expected to lead to the elucidation of the pathogenesis of neurodegenerative diseases such as ALS and FTD as well as to the development of therapeutic methods.
【Information on the outcome】
https://www.amed.go.jp/news/release_20210907.html (AMED)
https://www.naramed-u.ac.jp/university/kenkyu-sangakukan/oshirase/r3nendo/soubunriseigyo.html (Nara Medical Univ.)
Article
＜Title＞
C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
DOI : 10.1038/s41467-021-25560-0
＜Authors＞
Hitoki Nanaura#, Honoka Kawamukai#, Ayano Fujiwara#, Takeru Uehara, Yuichiro Aiba, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Pattama Wiriyasermkul, Sotaro Kikuchi, Riko Nagata, Masaya Matsubayashi, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Naritaka Morikawa, Naohiko Iguchi, Takao Kiriyama, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Takashi Oda, Noriyuki Kodera, Sachiko Toma-Fukai, Mamoru Sato, Hideki Taguchi, Shushi Nagamori, Osami Shoji, Koichiro Ishimori, Hiroyoshi Matsumura, Kazuma Sugie, Tomohide Saio*, Takuya Yoshizawa*, Eiichiro Mori* (＃：Equal contribution)（*：Corresponding author）
＜Journal＞
Nature Communications