Clinical Relevance of Brain Functional Connectome Uniqueness in Major Depressive Disorder
Summary
A research group led by Project Researcher Siti Nurul Zhahara, Professor Yoshiyuki Hirano, and Professor Eiji Shimizu at Chiba University, along with Professor Tsuyoshi Okada at Hiroshima University, now points to functional connectome uniqueness (an individual-level measure from brain fingerprinting that captures how distinctive a person’s intrinsic connectivity patterns are) as a reliable framework for discovering neurobiological biomarkers of major depressive disorder (MDD).
This approach of individual connectivity profiles may cut through study heterogeneity and enhance reproducibility in biomarker research for MDD.
【Information on the outcome】
https://www.chiba-u.ac.jp/news/research-collab/post_606.html （千葉大学）
https://www.amed.go.jp/news/seika/2026_seika_index.html （AMED）
Article
＜Title＞
Reduced functional connectome uniqueness on the whole brain and network levels as a clinically relevant and reproducible neuroimaging marker in major depressive disorder
DOI: 10.1016/j.jad.2025.121073
＜Authors＞
Siti Nurul Zhahara, Yusuke Sudo, Kohei Kurita, Eri Itai, Toshiharu Kamishikiryo, Hitomi Kitagawa, Tokiko Yoshida, Junbing He, Rio Kamashita, Yuko Isobe, Yuki Ikemizu, Koji Matsumoto, Go Okada, Eiji Shimizu, Yoshiyuki Hirano
＜Journal＞
Journal of Affective Disorders , April